Genetics Underlying an Individualized Approach to Adult Spinal Disorders

Authors

Corey T. Walker, Department of Neurosurgery, St. Joseph's Hospital and Medical Center, Barrow Neurological Institute , Phoenix, AZ , USA.
Phillip A. Bonney, Department of Neurosurgery, St. Joseph's Hospital and Medical Center, Barrow Neurological Institute , Phoenix, AZ , USA.
Nikolay L. Martirosyan, Department of Neurosurgery, St. Joseph's Hospital and Medical Center, Barrow Neurological Institute , Phoenix, AZ , USA.Follow
Nicholas Theodore, Department of Neurosurgery, St. Joseph's Hospital and Medical Center, Barrow Neurological Institute , Phoenix, AZ , USA.

Document Type

Article

Abstract

Adult spinal disorders are a significant cause of morbidity across the world and carry significant health and economic burdens. Genetic predispositions are increasingly considered for these conditions and are becoming understood. Advances in molecular technologies since the mid-1990s have made possible genetic characterizations of these diseases in many populations, and recent findings have provided insight into the underlying pathophysiologic mechanisms. These studies have made clear the genetic heterogeneity producing clinical phenotypes and suggest that individualized treatments are possible in the future. We review the genetics and heritability of cervical spondylotic myelopathy and ossification of the posterior longitudinal ligament and perform a systematic review of the genetics of adult lumbar degenerative scoliotic deformity, highlighting recent discoveries and the potential for personalized future therapeutics for these patients.

Publication Date

1-1-2016

Publication Title

Frontiers in surgery

ISSN

2296-875X

Volume

3

First Page

61

PubMed ID

27921035

Recommended Citation

Walker, Corey T.; Bonney, Phillip A.; Martirosyan, Nikolay L.; and Theodore, Nicholas, "Genetics Underlying an Individualized Approach to Adult Spinal Disorders" (2016). Neurosurgery. 1687.
https://scholar.barrowneuro.org/neurosurgery/1687