Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions
Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysms implicates inflammation as a critical mediator of aneurysm pathogenesis. Thus, therapeutic targets exploiting this arm of aneurysm pathogenesis have been implemented, often with promising outcomes.
Frontiers in surgery
Digital Object Identifier (DOI)
Fennell, Vernard S.; Kalani, M Yashar; Atwal, Gursant; Martirosyan, Nikolay L.; and Spetzler, Robert F., "Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions" (2016). Neurosurgery. 1668.