Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions

Authors

Vernard S. Fennell, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
M Yashar Kalani, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.Follow
Gursant Atwal, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.
Nikolay L. Martirosyan, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.Follow
Robert F. Spetzler, Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix, AZ , USA.

Document Type

Article

Abstract

Understanding the biology of intracranial aneurysms is a clinical quandary. How these aneurysms form, progress, and rupture is poorly understood. Evidence indicates that well-established risk factors play a critical role, along with immunologic factors, in their development and clinical outcomes. Much of the expanding knowledge of the inception, progression, and rupture of intracranial aneurysms implicates inflammation as a critical mediator of aneurysm pathogenesis. Thus, therapeutic targets exploiting this arm of aneurysm pathogenesis have been implemented, often with promising outcomes.

Publication Date

1-1-2016

Publication Title

Frontiers in surgery

ISSN

2296-875X

Volume

3

First Page

43

PubMed ID

27504449

Digital Object Identifier (DOI)

10.3389/fsurg.2016.00043

Recommended Citation

Fennell, Vernard S.; Kalani, M Yashar; Atwal, Gursant; Martirosyan, Nikolay L.; and Spetzler, Robert F., "Biology of Saccular Cerebral Aneurysms: A Review of Current Understanding and Future Directions" (2016). Neurosurgery. 1668.
https://scholar.barrowneuro.org/neurosurgery/1668