Bone metastasis from glioblastoma: a systematic review

Authors

Michael J. Strong, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Sravanthi Koduri, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Jodi A. Allison, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.
Cecilia M. Pesavento, University of Michigan School of Medicine, Ann Arbor, MI, 48109, USA.
Sebele Ogunsola, Western Michigan University School of Medicine, Kalamazoo, MI, 49008, USA.
Oludotun Ogunsola, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Timothy J. Yee, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Siri Sahib Khalsa, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Yamaan S. Saadeh, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Jacob R. Joseph, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Osama N. Kashlan, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Paul Park, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Mark E. Oppenlander, Department of Neurosurgery, University of Michigan, Ann Arbor, MI, 48109, USA.
Nicholas J. Szerlip, Department of Neurosurgery, University of Michigan, 3552 Taubman Center, SPC 5338, 1500 E. Medical Center Dr, Ann Arbor, MI, 48109, USA. nszerlip@med.umich.edu.

Document Type

Article

Abstract

INTRODUCTION: Glioblastoma (GBM) is a devastating disease with poor overall survival. Despite the common occurrence of GBM among primary brain tumors, metastatic disease is rare. Our goal was to perform a systematic literature review on GBM with osseous metastases and understand the rate of metastasis to the vertebral column as compared to the remainder of the skeleton, and how this histology would fit into our current paradigm of treatment for bone metastases. METHODS: A Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant literature search was performed using the PubMed database from 1952 to 2021. Search terms included "GBM", "glioblastoma", "high-grade glioma", "bone metastasis", and "bone metastases". RESULTS: Of 659 studies initially identified, 67 articles were included in the current review. From these 67 articles, a total of 92 distinct patient case presentations of metastatic glioblastoma to bone were identified. Of these cases, 58 (63%) involved the vertebral column while the remainder involved lesions within the skull, sternum, rib cage, and appendicular skeleton. CONCLUSION: Metastatic dissemination of GBM to bone occurs. While the true incidence is unknown, workup for metastatic disease, especially involving the spinal column, is warranted in symptomatic patients. Lastly, management of patients with GBM vertebral column metastases can follow the International Spine Oncology Consortium two-step multidisciplinary algorithm for the management of spinal metastases.

Medical Subject Headings

Bone Neoplasms (secondary); Brain Neoplasms (pathology, therapy); Glioblastoma (pathology); Humans; Spine (pathology)

Publication Date

7-1-2022

Publication Title

Journal of neuro-oncology

E-ISSN

1573-7373

Volume

158

Issue

3

First Page

379

Last Page

392

PubMed ID

35578056

Digital Object Identifier (DOI)

10.1007/s11060-022-04025-4

Recommended Citation

Strong, Michael J.; Koduri, Sravanthi; Allison, Jodi A.; Pesavento, Cecilia M.; Ogunsola, Sebele; Ogunsola, Oludotun; Yee, Timothy J.; Khalsa, Siri Sahib; Saadeh, Yamaan S.; Joseph, Jacob R.; Kashlan, Osama N.; Park, Paul; Oppenlander, Mark E.; and Szerlip, Nicholas J., "Bone metastasis from glioblastoma: a systematic review" (2022). Neurosurgery. 1607.
https://scholar.barrowneuro.org/neurosurgery/1607