Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-6 -174G>C and -572G>C (Part II)

Authors

Alice Giotta Lucifero, Neurosurgery Unit, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy. Alicelucifero@gmail.com.
Matias Baldoncini, Department of Neurological Surgery, Hospital San Fernando, Buenos Aires, Argentina, . drbaldoncinimatias@gmail.com.
Ilaria Brambilla, Pediatric Clinic, IRCCS Policlinico San Matteo Foundation, University of Pavia, Pavia, Italy. i.brambilla@smatteo.pv.it.
Monica Rutigliano, Department of Emergency and Organ Transplantation, Urology, Andrology and Kidney Transplantation Unit, University of Bari, Bari, Italy. monica.rutigliano4@gmail.com.
Gabriele Savioli, Emergency Medicine and Surgery, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy. gabrielesavioli@gmail.com.
Renato Galzio, Neurosurgery Unit, Maria Cecilia Hospital, Cotignola, Italy. renato.galzio@gmail.com.
Alvaro Campero, Servicio de Neurocirugía, Universidad Nacional de Tucumán; Argentina; Department of Neurosurgery, Hospital Padilla, San Miguel de Tucumán, Tucumán, Argentina. alvarocampero@yahoo.com.ar.
Michael T. Lawton, Department of Neurosurgery, Barrow Neurological Institute (BNI), United States. michael.lawton@barrowbrainandspine.com.Follow
Sabino Luzzi, Neurosurgery Unit, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; Neurosurgery Unit, Department of Surgical Sciences, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.. sabino.luzzi@unipv.it.

Document Type

Article

Abstract

Introduction The interleukin-6 (IL-6), a proinflammatory cytokine, supports the adaptive immune response and regulates inflammatory processes. The -174 G>C and -572 G>C promoter polymorphisms of the IL-6 gene take part in the pathogenesis of intracranial aneurysms (IAs) and influence the clinical presentation of subarachnoid hemorrhage. This meta-analysis purposes to evaluate whether and which IL-6 allelic variations are related to a risk of IAs formation. Methods A PRISMA-based literature search was performed on the PubMed/Medline and Web of Science databases. The keywords used were "interleukin-6," "IL-6," "polymorphism," "interleukin-6 genotype," combined with "intracranial aneurysms" and "subarachnoid hemorrhage." Only human case-control studies, with a study (IAs) and a control group, written in English, and published in the last 15 years were selected. A meta-analysis was performed, estimating odds ratios and 95% confidence intervals in fixed- or random-effects models, as applicable. Statistical analysis was conducted with RevMan 5.0 software. Results 9 studies were eligible. No associations were found between -174 G>C polymorphisms and IAs susceptibility. Notable results were reported by the analysis of -572G>C polymorphisms. -572GG/GC/CC genotypes were strongly related to IAs occurrence with a statistical significance of p=0.03, p=0.0009, and p=0.00001, respectively. Conclusion A higher incidence of -572G>C promoter polymorphisms were demonstrated in the IAs group, highlighting the pivotal role of inflammatory genes in the natural history of brain aneurysms. Additional studies are required considering the racial heterogenicity and the need to widen the population sample.

Medical Subject Headings

Genetic Predisposition to Disease; Humans; Interleukin-6 (genetics); Intracranial Aneurysm (genetics); Polymorphism, Genetic; Subarachnoid Hemorrhage (genetics)

Publication Date

3-21-2022

Publication Title

Acta bio-medica : Atenei Parmensis

E-ISSN

2531-6745

Volume

92

Issue

S4

First Page

e2021420

PubMed ID

35441611

Digital Object Identifier (DOI)

10.23750/abm.v92iS4.12669

Recommended Citation

Giotta Lucifero, Alice; Baldoncini, Matias; Brambilla, Ilaria; Rutigliano, Monica; Savioli, Gabriele; Galzio, Renato; Campero, Alvaro; Lawton, Michael T.; and Luzzi, Sabino, "Gene Polymorphisms Increasing the Risk of Intracranial Aneurysms: Interleukin-6 -174G>C and -572G>C (Part II)" (2022). Neurosurgery. 1576.
https://scholar.barrowneuro.org/neurosurgery/1576