Dorsal Laminectomy in the Adult Mouse: A Model for Nervous System Research

Authors

Dilantha B. Ellegala, University of Washington School of Medicine
J. Channing Tassone, University of Washington School of Medicine
Anthony M. Avellino, VA Medical Center
Cynthia A. Pekow, VA Medical Center
Michael L. Cunningham, University of Washington
Michel Kliot, VA Medical Center

Document Type

Article

Abstract

Animal strains with specific genetic mutations can serve as powerful tools to study normal and pathologic cellular and molecular processes. The mammalian species with the largest number of known genetic mutations is the mouse. In spinal cord research, mice have not been used as extensively as other species because of the difficulty in accessing and manipulating their spinal cord. We describe the technique of exposing and manipulating the spinal cord of normal mice and of mice with the severe combined immunodeficiency (scid) mutation. Surgical outcome and complications are discussed. We conclude that dorsal laminectomy with subsequent access and manipulation of the spinal cord and its roots can be accomplished consistently with practice.

Publication Date

12-1-1996

Publication Title

Laboratory Animal Science

ISSN

00236764

Volume

46

Issue

1

First Page

86

Last Page

89

PubMed ID

8699828

Recommended Citation

Ellegala, Dilantha B.; Channing Tassone, J.; Avellino, Anthony M.; Pekow, Cynthia A.; Cunningham, Michael L.; and Kliot, Michel, "Dorsal Laminectomy in the Adult Mouse: A Model for Nervous System Research" (1996). Neurosurgery. 1515.
https://scholar.barrowneuro.org/neurosurgery/1515