EBV-positive B cell cerebral lymphoma 12 years after sex-mismatched kidney transplantation: post-transplant lymphoproliferative disorder or donor-derived lymphoma?

Document Type

Article

Abstract

We present a follow-up case report of possible transmission of lymphoma 12 years after deceased-donor renal transplantation from a male donor who was found at autopsy to have had an occult lymphoma. The female recipient underwent prompt transplant nephrectomy. However, 12 years later, she presented with cerebral B cell lymphoma. A donor origin for the cerebral lymphoma was supported by in situ hybridization demonstration of a Y chromosome in the lymphoma. There was a dramatic resolution of the cerebral lesions with tapering of immunosuppression and introduction of rituximab treatment. The finding of a Y chromosome in the cerebral lymphoma does not exclude a host contribution to lymphoma development.

Medical Subject Headings

Adult; Brain Neoplasms (etiology, genetics, virology); Chromosomes, Human, Y (genetics); Epstein-Barr Virus Infections (etiology); Female; Herpesvirus 4, Human (genetics, isolation & purification); Humans; In Situ Hybridization; Kidney Transplantation (adverse effects); Lymphoma, B-Cell (etiology, genetics, virology); Lymphoproliferative Disorders (etiology, genetics, virology); Male; Middle Aged; Time Factors; Tissue Donors

Publication Date

6-1-2010

Publication Title

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

E-ISSN

1460-2385

Volume

25

Issue

6

First Page

2032

Last Page

5

PubMed ID

20348150

Digital Object Identifier (DOI)

10.1093/ndt/gfq170

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