Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation

Authors

Yi Guo, Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA ; Department of Neurosurgery, Affiliated Hospital of Hebei University, Baoding 071000 China.
Tarik Tihan, Department of Pathology, University of California, San Francisco, San Francisco, CA 94110, USA.
Helen Kim, Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.
Christopher Hess, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94110, USA.
Michael T. Lawton, Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94110, USA.Follow
William L. Young, Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA ; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94110, USA ; Department of Neurology, University of California, San Francisco, San Francisco, CA 94110, USA.
Yuanli Zhao, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 410011, China.Follow
Hua Su, Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94110, USA.

Document Type

Article

Abstract

AIM: To test the hypothesis that lymphocyte infiltration in brain arteriovenous malformation (bAVM) is not associated with iron deposition (indicator of microhemorrhage). METHODS: Sections of unruptured, previously untreated bAVM specimens (n=19) were stained immunohistochemically for T-lymphocytes (CD3), B-lymphocytes (CD20), plasma cells (CD138) and macrophages (CD68). Iron deposition was assessed by hematoxylin and eosin and Prussian blue stains. Superficial temporal arteries (STA) were used as control. RESULTS: Both T lymphocytes and macrophages were present in unruptured, previously untreated bAVM specimens, whereas few B cells and plasma cells were detected. Iron deposition was detected in 8 specimens (42%; 95% confidence interval =20-67%). The samples with iron deposition tended to have more macrophages than those without (666±313 vs 478±174 cells/mm; P=0.11). T-cells were clustered on the luminal side of the endothelial surface, on the vessel-wall, and in the perivascular regions. There was no correlation between T lymphocyte load and iron deposition (P=0.88). No macrophages and lymphocytes were detected in STA controls. CONCLUSIONS: T-lymphocytes were present in bAVM specimens. Unlike macrophages, the load and location of T-lymphocytes were not associated with iron deposition, suggesting the possibility of an independent cell-mediated immunological mechanism in bAVM pathogenesis.

Publication Date

1-9-2015

Publication Title

Neuroimmunology and neuroinflammation

ISSN

2347-8659

Volume

1

Issue

3

First Page

147

Last Page

152

PubMed ID

25568888

Digital Object Identifier (DOI)

10.4103/2347-8659.143674

Recommended Citation

Guo, Yi; Tihan, Tarik; Kim, Helen; Hess, Christopher; Lawton, Michael T.; Young, William L.; Zhao, Yuanli; and Su, Hua, "Distinctive distribution of lymphocytes in unruptured and previously untreated brain arteriovenous malformation" (2015). Neurosurgery. 1103.
https://scholar.barrowneuro.org/neurosurgery/1103