Diagnostic and Prognostic Implications of GNAS Inactivation in Sonic Hedgehog-Activated Medulloblastoma: Case Report with Comprehensive Molecular Profiling and Review of Literature

Authors

Erin Goode, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ.
Liliana Montoya, Division of Dermatology, Phoenix Children's Hospital, Phoenix, AZ.
Eric Graham, Department of Radiology, Phoenix Children's Hospital, Phoenix, AZ.
Brianna Pruniski, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ.
Curtis Simmons, Department of Radiology, Phoenix Children's Hospital, Phoenix, AZ.
Alexander Ngwube, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ.
Lindsey M. Hoffman, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ.
Nishant Tiwari, Department of Pathology, Phoenix Children's Hospital, Phoenix, AZ.
Kenneth Aldape, National Institutes of Health, Bethesda, MD.
Harper N. Price, Division of Dermatology, Phoenix Children's Hospital, Phoenix, AZ.
Vera Paulson, Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA.
Ross Mangum, Center for Cancer and Blood Disorders, Phoenix Children's Hospital, Phoenix, AZ.

Document Type

Article

Medical Subject Headings

Cerebellar Neoplasms (diagnosis); Chromogranins (genetics); GTP-Binding Protein alpha Subunits, Gs (genetics); Hedgehog Proteins (genetics); Humans; Medulloblastoma (diagnosis); Prognosis; Signal Transduction

Publication Date

3-1-2022

Publication Title

JCO precision oncology

E-ISSN

2473-4284

Volume

6

First Page

e2100403

PubMed ID

35357904

Digital Object Identifier (DOI)

10.1200/PO.21.00403

Recommended Citation

Goode, Erin; Montoya, Liliana; Graham, Eric; Pruniski, Brianna; Simmons, Curtis; Ngwube, Alexander; Hoffman, Lindsey M.; Tiwari, Nishant; Aldape, Kenneth; Price, Harper N.; Paulson, Vera; and Mangum, Ross, "Diagnostic and Prognostic Implications of GNAS Inactivation in Sonic Hedgehog-Activated Medulloblastoma: Case Report with Comprehensive Molecular Profiling and Review of Literature" (2022). Neuropathology. 8.
https://scholar.barrowneuro.org/neuropathology/8