Amniotic Membrane Augmentation for Enucleation After Chemotherapy in Retinoblastoma
Document Type
Article
Abstract
PURPOSE: To describe amniotic membrane augmentation for enucleation after chemotherapy in retinoblastoma. METHODS: This was a retrospective study of patients with retinoblastoma who underwent enucleation. The study also evaluated the utility of amniotic membrane grafting in enucleation after chemotherapy in eyes with retinoblastoma. RESULTS: In this study, 110 eyes of 107 patients were analyzed, and 49 patients had previous systemic chemotherapy, 13 eyes had previous intra-arterial chemotherapy, and 7 eyes had external beam radiation. Amniotic graft was used in 8 eyes (5 following IAC, 2 following systemic chemotherapy, and 1 after both). After IAC, 3 of 7 eyes without amniotic graft had implant exposure compared to 0 of 6 eyes with amniotic graft ( = .05). Pathological examination of the conjunctiva after intra-arterial chemotherapy showed goblet cell hypoplasia that hinders wound healing. CONCLUSIONS: Amniotic membrane augmentation improves wound integrity in patients with retinoblastoma, especially following intra-arterial chemotherapy. .
Publication Date
4-25-2024
Publication Title
Journal of pediatric ophthalmology and strabismus
E-ISSN
1938-2405
First Page
1
Last Page
6
PubMed ID
38661308
Digital Object Identifier (DOI)
10.3928/01913913-20240307-01
Recommended Citation
Ramasubramanian, Aparna; Rehman, Nisha S.; Chauhan, Argudit; Rodriguez, Aurora; Leverant, Amy; and Tiwari, Nishant, "Amniotic Membrane Augmentation for Enucleation After Chemotherapy in Retinoblastoma" (2024). Neuropathology. 2.
https://scholar.barrowneuro.org/neuropathology/2