Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease: An EU/US CTAD Task Force Report
Document Type
Article
Abstract
While amyloid-targeting therapies continue to predominate in the Alzheimer’s disease (AD) drug development pipeline, there is increasing recognition that to effectively treat the disease it may be necessary to target other mechanisms and pathways as well. In December 2019, The EU/US CTAD Task Force discussed these alternative approaches to disease modification in AD, focusing on tau-targeting therapies, neurotrophin receptor modulation, anti-microbial strategies, and the innate immune response; as well as vascular approaches, aging, and non-pharmacological approaches such as lifestyle intervention strategies, photobiomodulation and neurostimulation. The Task Force proposed a general strategy to accelerate the development of alternative treatment approaches, which would include increased partnerships and collaborations, improved trial designs, and further exploration of combination therapy strategies.
Publication Date
3-1-2020
Publication Title
Journal of Prevention of Alzheimer's Disease
ISSN
22745807
E-ISSN
24260266
Volume
7
Issue
3
First Page
152
Last Page
157
PubMed ID
32420298
Digital Object Identifier (DOI)
10.14283/jpad.2020.18
Recommended Citation
Gauthier, Serge; Aisen, P. S.; Cummings, J.; Detke, M. J.; Longo, F. M.; Raman, R.; Sabbagh, M.; Schneider, L.; Tanzi, R.; Tariot, P.; Weiner, M.; Touchon, J.; and Vellas, B., "Non-Amyloid Approaches to Disease Modification for Alzheimer’s Disease: An EU/US CTAD Task Force Report" (2020). Neurology. 964.
https://scholar.barrowneuro.org/neurology/964