Neuropathologic heterogeneity does not impair florbetapir-positron emission tomography postmortem correlates
Document Type
Article
Abstract
Neuropathologic heterogeneity is often present among Alzheimer disease (AD) patients. We sought to determine whether amyloid imaging measures of AD are affected by concurrent pathologies. Thirty-eight clinically and pathologically defined AD and 17 nondemented patients with quantitative florbetapir F-18 (F-AV-45) positron emission tomography (PET) imaging during life and postmortem histological β-amyloid quantification and neuropathologic examination were assessed. AD patients were divided on the basis of concurrent pathologies, including those with Lewy bodies (LBs) (n = 21), white matter rarefaction (n = 27), severe cerebral amyloid angiopathy (n = 11), argyrophilic grains (n = 5), and TAR DNA binding protein-43 inclusions (n = 18). Many patients exhibited more than 1 type of concurrent pathology. The ratio of cortical to cerebellar amyloid imaging signal (SUVr) and immunohistochemical β-amyloid load were analyzed in 6 cortical regions of interest. All AD subgroups had strong and significant correlations between SUVr and histological β-amyloid measures (p μ 0.001). All AD subgroups had significantly greater amyloid measures versus nondemented patients, and mean amyloid measures did not significantly differ between AD subgroups. When comparing AD cases with and without each pathology, AD cases with LBs had significantly lower SUVr measures versus AD cases without LBs (p = 0.002); there were no other paired comparison differences. These findings indicate that florbetapir-PET imaging is not confounded by neuropathological heterogeneity within AD. © 2013 by the American Association of Neuropathologists,Inc.
Publication Date
1-1-2014
Publication Title
Journal of Neuropathology and Experimental Neurology
ISSN
00223069
E-ISSN
15546578
Volume
73
Issue
1
First Page
72
Last Page
80
PubMed ID
24335535
Digital Object Identifier (DOI)
10.1097/NEN.0000000000000028
Recommended Citation
Dugger, Brittany N.; Clark, Christopher M.; Serrano, Geidy; Mariner, Monica; Bedell, Barry J.; Coleman, R. Edward; Doraiswamy, P. Murali; Lu, Ming; Fleisher, Adam S.; Reiman, Eric M.; Sabbagh, Marwan N.; Sadowsky, Carl H.; Schneider, Julie A.; Zehntner, Simone P.; Carpenter, Alan P.; Joshi, Abhinay D.; Mintun, Mark A.; Pontecorvo, Michael J.; Skovronsky, Daniel M.; Sue, Lucia I.; and Beach, Thomas G., "Neuropathologic heterogeneity does not impair florbetapir-positron emission tomography postmortem correlates" (2014). Neurology. 952.
https://scholar.barrowneuro.org/neurology/952