Investigational drugs in Alzheimer's disease: Current progress

Document Type

Article

Abstract

Introduction: Alzheimer's disease is a progressive neurodegenerative disorder affecting millions of people worldwide. Yet, this disease is presently incurable and treatable only in terms of modest delay of symptomatic progression. The need for more effective pharmacological intervention is becoming more pronounced as the patient population increases. Areas covered: This paper outlines and evaluates the current landscape of interventions in early phases of clinical study. Data and analysis for this review were procured from PubMed, clinicaltrials.gov, review of posters, abstracts and presentations from American Neurological Association, American Academy of Neurology meetings, Alzheimer's Association International Conference and Clinical Trials on Alzheimer's disease. Keywords and criteria searched included: Phase 0, I, and II trials related to Alzheimer's disease, amyloid-β, anti-tau, monoclonal antibodies and metabolism. Expert opinion: The development of novel pharmacological interventions would be more fruitful if multitarget therapies were introduced, and unexplored mechanisms of action were expanded upon. Additionally, there is a rationale for intervening earlier in the disease, perhaps preceding or at the advent of symptoms. © 2014 Informa UK, Ltd.

Publication Date

1-1-2014

Publication Title

Expert Opinion on Investigational Drugs

ISSN

13543784

E-ISSN

17447658

Volume

23

Issue

6

First Page

837

Last Page

846

PubMed ID

24702504

Digital Object Identifier (DOI)

10.1517/13543784.2014.905542

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