Incidental Lewy body disease: Electrophysiological findings suggesting pre-clinical Lewy body disorders

Document Type

Article

Abstract

Objective: Evaluate electrophysiologic findings in incidental Lewy body disease (ILBD). Methods: ILBD, Control, and Parkinson's disease (PD) subjects had electrophysiological evaluation within 2. years prior to autopsy. Data analyzed included surface electromyography (EMG) of upper extremity muscles during rest and muscle activation, and electroencephalography (EEG) recording at rest. For EMG, gross tracings and spectral peaks were analyzed. EEG measures analyzed were background frequency and power in delta, theta, alpha, and beta bands. Results: Three of ten ILBD subjects (30%) showed unilateral rhythmic EMG discharges at rest without a visually apparent rest tremor. The ILBD resting EMG frequency was lower than in the Control group with no overlap (P=.03) and close to that of the PD group. The ILBD group had significantly lower background rhythm frequency than the Control group (P=.001) but was greater than the PD group (P=.01). Conclusions: The electrophysiologic changes in ILBD cases are between those of Control and PD, suggesting that these findings may reflect changes correlating with ILBD as a possible precursor to PD. Significance: Electrophysiologic changes in ILBD may assist with the identification of a preclinical stage for Lewy body disorders and help the development of a therapeutic agent for modifying Lewy body disease progression. © 2011 International Federation of Clinical Neurophysiology.

Publication Date

12-1-2011

Publication Title

Clinical Neurophysiology

ISSN

13882457

E-ISSN

18728952

Volume

122

Issue

12

First Page

2426

Last Page

2432

PubMed ID

21616709

Digital Object Identifier (DOI)

10.1016/j.clinph.2011.03.033

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