Disease-modifying approaches to Alzheimer's disease: Challenges and opportunities-Lessons from donepezil therapy
Document Type
Article
Abstract
The era of disease modification as a therapeutic option for Alzheimer's disease (AD) is upon us. With dozens of novel drugs in development, there is more need than ever to develop biomarkers that distinguish normal aging from AD and AD from other dementias, track changes over time as disease progresses, and respond to interventions. Future trials will need to weight biomarker outcomes equal to cognitive outcomes especially when the biomarkers are linked to specific mechanisms, such as changes to beta amyloid (Aβ) deposition or brain volume. Since the advent of donepezil as a treatment for AD, new mechanisms of action of this molecule have been discovered. In this perspective, we review trial design and discuss the use of biomarkers by using lessons learned from previous trials conducted with cholinergic therapy. © 2008 The Alzheimer's Association.
Publication Date
1-1-2008
Publication Title
Alzheimer's and Dementia
ISSN
15525260
Volume
4
Issue
1 SUPPL. 1
PubMed ID
18631986
Digital Object Identifier (DOI)
10.1016/j.jalz.2007.11.013
Recommended Citation
Sabbagh, Marwan N.; Richardson, Sharon; and Relkin, Norman, "Disease-modifying approaches to Alzheimer's disease: Challenges and opportunities-Lessons from donepezil therapy" (2008). Neurology. 846.
https://scholar.barrowneuro.org/neurology/846