Comment on administration and scoring of the Neuropsychiatric Inventory in clinical trials
Background: The Neuropsychiatric Inventory (NPI) is commonly used in dementia trials to quantify and qualitate changes in psychiatric symptoms. Methods: A questionnaire was administered to clinical trial raters to assess whether they were being trained to administer and score the NPI differently between clinical trial protocols. Results: Responses to the survey indicated that there are differences between clinical trials protocols in how the instrument is administered and scored. Discussion: Clarification of administration and scoring rules are provided, including the behavioral sampling period, whether premorbid characteristics are considered, and what behaviors are considered in rating frequency, severity, and caregiver distress. © 2008 The Alzheimer's Association.
Alzheimer's and Dementia
Digital Object Identifier (DOI)
Connor, Donald J.; Sabbagh, Marwan N.; and Cummings, Jeffery L., "Comment on administration and scoring of the Neuropsychiatric Inventory in clinical trials" (2008). Neurology. 819.