Title

Comment on administration and scoring of the Neuropsychiatric Inventory in clinical trials

Document Type

Editorial

Abstract

Background: The Neuropsychiatric Inventory (NPI) is commonly used in dementia trials to quantify and qualitate changes in psychiatric symptoms. Methods: A questionnaire was administered to clinical trial raters to assess whether they were being trained to administer and score the NPI differently between clinical trial protocols. Results: Responses to the survey indicated that there are differences between clinical trials protocols in how the instrument is administered and scored. Discussion: Clarification of administration and scoring rules are provided, including the behavioral sampling period, whether premorbid characteristics are considered, and what behaviors are considered in rating frequency, severity, and caregiver distress. © 2008 The Alzheimer's Association.

Publication Date

11-1-2008

Publication Title

Alzheimer's and Dementia

ISSN

15525260

Volume

4

Issue

6

First Page

390

Last Page

394

PubMed ID

19012863

Digital Object Identifier (DOI)

10.1016/j.jalz.2008.09.002

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