Clinical characterization of mild cognitive impairment as a prodrome to dementia with lewy bodies

Document Type

Article

Abstract

Limited information regarding the specificity of mild cognitive impairment (MCI) as it relates to dementia with Lewy bodies (DLB) exists. Here, we summarize the clinical phenotype of MCI in clinically suspect DLB. Ten patients with a primary diagnosis of MCI and secondary diagnoses of DLB were identified. Patients underwent clinical neurological and neuropsychological evaluation that included application of McKeith criteria. We found parkinsonism and gait abnormality in 9 of the 10 patients; fluctuations in 8 of the 10; and hallucinations and dream enactment behavior in 5 of the 10. Of the 10 cases, 4 were classified as nonamnestic MCI and 6 were amnestic MCI. Of the 10 cases, 9 displayed executive and/or visuospatial dysfunction. Of the 10 cases, 6 have progressed to DLB. Progression of MCI to DLB is not dependent on memory impairment. The presence of core clinical features - parkinsonism and cognitive fluctuations - and predominant executive and visuospatial dysfunction ± memory impairment is suggestive of a prodromal DLB presentation.

Publication Date

3-25-2015

Publication Title

American Journal of Alzheimer's Disease and other Dementias

ISSN

15333175

E-ISSN

19382731

Volume

30

Issue

2

First Page

173

Last Page

177

PubMed ID

25013117

Digital Object Identifier (DOI)

10.1177/1533317514542642

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