Broader considerations of higher doses of donepezil in the treatment of mild, moderate, and severe alzheimer's disease
Document Type
Article
Abstract
Donepezil, a highly selective acetylcholinesterase inhibitor (AChEI), is approved as a symptomatic treatment mild, moderate, and severe Alzheimer's disease (AD). Donepezil exerts its treatment effect through multiple mechanisms of action including nicotinic receptor stimulation, mitigation of excitotoxicity, and influencing APP processing. The use of donepezil at higher doses is justified given the worsening cholinergic deficit as the disease advances. Donepezil has been investigated in several clinical trials of subjects with moderate-to-severe AD. While the side effects are class specific (cholinergically driven), demonstrable benefit has been shown at the 10mg dose and the 23mg doses. Here, we review the clinical justification, efficacy, safety, and tolerability of use of donepezil in the treatment of moderate-to-severe AD. © 2012 Camryn Berk and Marwan Sabbagh.
Publication Date
1-12-2012
Publication Title
International Journal of Alzheimer's Disease
E-ISSN
20900252
PubMed ID
22191061
Digital Object Identifier (DOI)
10.1155/2012/707468
Recommended Citation
Berk, Camryn and Sabbagh, Marwan, "Broader considerations of higher doses of donepezil in the treatment of mild, moderate, and severe alzheimer's disease" (2012). Neurology. 787.
https://scholar.barrowneuro.org/neurology/787