Both early and late cognitive dysfunction affects the electroencephalogram in Parkinson's disease

Document Type

Article

Abstract

We sought to define quantitative electroencephalographic (EEG) measures as biomarkers of both early and late cognitive decline in Parkinson's disease (PD). PD subjects classified as cognitively normal (PD-CogNL), mild cognitive impairment (PD-MCI), and dementia (PD-D) were studied. Cognitive status and neuropsychological testing was correlated with background rhythm and frequency band EEG power across five frequency bands. We conclude that global EEG measures have potential use as biomarkers in the study of both early and late cognitive deterioration in PD, including for evaluating its treatment. PD-MCI has mean quantitative EEG characteristics that represent an intermediate electrophysiological state between PD-CogNL and PD-D. © 2007 Elsevier Ltd. All rights reserved.

Publication Date

8-1-2007

Publication Title

Parkinsonism and Related Disorders

ISSN

13538020

Volume

13

Issue

6

First Page

348

Last Page

354

PubMed ID

17347022

Digital Object Identifier (DOI)

10.1016/j.parkreldis.2007.01.003

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