Amyloid accumulation in Down syndrome measured with amyloid load
Introduction: Individuals with Down syndrome (DS) show enhanced amyloid beta (Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid load ( ) was recently developed as an alternative to standardized uptake value ratios (SUVrs) to quantify Aβ burden with high sensitivity for detecting and tracking Aβ change.. Methods: was calculated in a DS cohort (N = 169, mean age ± SD = 39.6 ± 8.7 years) using [C-11]Pittsburgh compound B (PiB) PET imaging. DS-specific PiB templates were created for Aβ carrying capacity () and non-specific binding (). Results: The highest values of Aβ carrying capacity were found in the striatum and precuneus. Longitudinal changes in displayed less variability when compared to SUVrs. Discussion: These results highlight the utility of for characterizing Aβ deposition in DS. Rates of Aβ accumulation in DS were found to be similar to that observed in late-onset Alzheimer's disease (AD; ≈3% to 4% per year), suggesting that AD progression in DS is of earlier onset but not accelerated.
Alzheimer's & dementia (Amsterdam, Netherlands)
Digital Object Identifier (DOI)
Zammit, Matthew D.; Laymon, Charles M.; Betthauser, Tobey J.; Cody, Karly A.; Tudorascu, Dana L.; Minhas, Davneet S.; Sabbagh, Marwan N.; Johnson, Sterling C.; Zaman, Shahid H.; Mathis, Chester A.; Klunk, William E.; Handen, Benjamin L.; Cohen, Ann D.; and Christian, Bradley T., "Amyloid accumulation in Down syndrome measured with amyloid load" (2020). Neurology. 752.