Amyloid accumulation in Down syndrome measured with amyloid load

Document Type

Article

Abstract

Introduction: Individuals with Down syndrome (DS) show enhanced amyloid beta (Aβ) deposition in the brain. A new positron emission tomography (PET) index of amyloid load ( ) was recently developed as an alternative to standardized uptake value ratios (SUVrs) to quantify Aβ burden with high sensitivity for detecting and tracking Aβ change.. Methods: was calculated in a DS cohort (N = 169, mean age ± SD = 39.6 ± 8.7 years) using [C-11]Pittsburgh compound B (PiB) PET imaging. DS-specific PiB templates were created for Aβ carrying capacity () and non-specific binding (). Results: The highest values of Aβ carrying capacity were found in the striatum and precuneus. Longitudinal changes in displayed less variability when compared to SUVrs. Discussion: These results highlight the utility of for characterizing Aβ deposition in DS. Rates of Aβ accumulation in DS were found to be similar to that observed in late-onset Alzheimer's disease (AD; ≈3% to 4% per year), suggesting that AD progression in DS is of earlier onset but not accelerated.

Publication Date

1-1-2020

Publication Title

Alzheimer's & dementia (Amsterdam, Netherlands)

ISSN

2352-8729

Volume

12

Issue

1

First Page

e12020

PubMed ID

32435686

Digital Object Identifier (DOI)

10.1002/dad2.12020

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