Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness

Document Type

Article

Abstract

© 2016 the Alzheimer's Association Introduction The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers. Methods Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar). Results Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness. Discussion In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.

Publication Date

2-1-2017

Publication Title

Alzheimer's and Dementia

ISSN

15525260

Volume

13

Issue

2

First Page

168

Last Page

177

PubMed ID

27461490

Digital Object Identifier (DOI)

10.1016/j.jalz.2016.06.2359

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