Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging
© 2020 - IOS Press and the authors. All rights reserved. We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged ≥50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score ≥13) and anxiety (Beck Anxiety Inventory score ≥10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.
Journal of Alzheimer's Disease
Digital Object Identifier (DOI)
Krell-Roesch, Janina; Syrjanen, Jeremy A.; Mielke, Michelle M.; Christianson, Teresa J.; Kremers, Walter K.; MacHulda, Mary M.; Knopman, David S.; Petersen, Ronald C.; Vassilaki, Maria; and Geda, Yonas E., "Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging" (2020). Neurology. 335.