Association between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging

Document Type

Article

Abstract

© 2020 - IOS Press and the authors. All rights reserved. We examined the associations between baseline neuropsychiatric symptoms (NPS) and longitudinal changes in functional performance among 5,394 non-demented individuals aged ≥50 years (2,729 males; median age 74.2 years; 4,716 cognitively unimpaired, 678 mild cognitive impairment). After adjusting for age, sex, education, and medical comorbidities, NPS assessed by the Neuropsychiatric Inventory Questionnaire, clinical depression (Beck Depression Inventory score ≥13) and anxiety (Beck Anxiety Inventory score ≥10) were significantly associated with an increase in the Functional Activities Questionnaire score, indicating functional decline over time. This association may vary depending on the degree of cognitive impairment at baseline.

Publication Date

1-1-2020

Publication Title

Journal of Alzheimer's Disease

ISSN

13872877

Volume

78

Issue

3

First Page

911

Last Page

917

PubMed ID

33074231

Digital Object Identifier (DOI)

10.3233/JAD-200764

This document is currently not available here.

Share

COinS