Pasireotide treatment does not modify hyperglycemic and corticosterone acute restraint stress responses in rats.

Department

Neuroendocrinology

Document Type

Article

Abstract

Pasireotide is a new-generation somatostatin analog that acts through binding to multiple somatostatin receptor subtypes. Studies have shown that pasireotide induces hyperglycemia, reduces glucocorticoid secretion, alters neurotransmission, and potentially affects stress responses typically manifested as hyperglycemia and increased corticosterone secretion. This study specifically aimed to evaluate whether pasireotide treatment modifies glucose and costicosterone secretion in response to acute restraint stress. Male Holtzman rats of 150-200 g were treated with pasireotide (10 µg/kg/day) twice-daily for two weeks or vehicle for the same period. Blood samples were collected at baseline and after 5, 10, 30, and 60 min of restraint stress. The three experimental groups comprised of vehicle + restraint (VEHR), pasireotide + restraint (PASR), and pasireotide + saline (PASNR). Following pasireotide treatment, no significant differences in baseline glucose and corticosterone levels were observed among the three groups. During restraint, hyperglycemia was observed at 10 min (p < .01 for both comparisons), peaked at 30 min (p < .01 for both comparisons) and showed higher 60 min areas under glucose curves in the VEHR and PASR stressed groups when compared to the non-stressed PASNR group (p < .05 for both comparisons). Restraint also increased corticosterone secretion in the VEHR and PASR stressed groups at 5 min (p < .01 for both comparisons), and peaked at 30 min (p < .01 for both comparisons) with corresponding higher 60 min areas under corticosterone curves when compared to the non-stressed PASNR group (p < .01 for both comparisons). In conclusion, pasireotide treatment does not modify hyperglycemic- and corticosterone-restraint stress responses, thus preserving acute stress regulation.

Medical Subject Headings

Animals; Blood Glucose; Corticosterone; Male; Rats; Rats, Sprague-Dawley; Restraint, Physical; Somatostatin; Stress, Physiological; Synaptic Transmission

Publication Date

7-1-2018

Publication Title

Stress (Amsterdam, Netherlands)

ISSN

1607-8888

Volume

21

Issue

4

First Page

370

Last Page

375

PubMed ID

29661114

Digital Object Identifier (DOI)

10.1080/10253890.2018.1451838

This document is currently not available here.

Share

COinS