EEG Stages Predict Treatment Response in Experimental Status Epilepticus
Department
neurology
Document Type
Article
Abstract
Progression of severity in experimental status epilepticus (SE), defined as refractoriness to first- and second-line abortive agents, may be related to a five-stage progression of electroencephalography (EEG) patterns. This was tested in the lithium-pilocarpine rat SE model. Abortive treatment with diazepam and phenobarbital was given at EEG stages I, III, and V. In stage I, the combination therapy resulted in 100% SE termination. However, stage III corresponded to high treatment resistance (0% abortion) and stage V to an intermediate response (63%). Comparisons of time-to-treatment durations showed overlap between stage I and stage III, despite having markedly different response rates to abortive medications. Therefore, EEG patterns reflect the dynamic pathophysiology of SE and can be used as reliable and specific markers to distinguish treatment-responsive from treatment-refractory SE more accurately than time alone.
Medical Subject Headings
neurology
Publication Date
2009
Publication Title
Epilepsia
ISSN
0013-9580
Volume
50
Issue
4
First Page
949
Last Page
952
Digital Object Identifier (DOI)
10.1111/j.1528-1167.2008.01911.x
Recommended Citation
Wang, Norman C.; Good, Levi B.; Marsh, Steven T.; and Treiman, David M., "EEG Stages Predict Treatment Response in Experimental Status Epilepticus" (2009). Neurology. 262.
https://scholar.barrowneuro.org/neurology/262