Title

Apoe 4 Polymorphism Results in Early Cognitive Deficits in an Eae Model

Department

neurology

Document Type

Article

Abstract

Recent clinical studies have identified an association between APOE 4 and cognitive deficits in patients with multiple sclerosis. We induced experimental autoimmune encephalomyelitis (EAE) in APOE knockout (KO) and human APOE 4 knockin (E4) mice to study the interaction of APOE and neuroinflammation on cognition. After EAE induction, KO and E4 showed significant deficits in spatial learning and recall. Regional decreases in choline acetyltransferase localized to the hippocampus. Induction of EAE in a transgenic APOE animal provides a template from which we can decipher the role APOE has on cognition in the context of neuroinflammation. © 2009 Elsevier Inc. All rights reserved.

Medical Subject Headings

neurology

Publication Date

2009

Publication Title

Biochemical and Biophysical Research Communications

ISSN

0006291X

Volume

384

Issue

4

First Page

466

Last Page

470

Digital Object Identifier (DOI)

10.1016/j.bbrc.2009.04.153

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