Apoe 4 Polymorphism Results in Early Cognitive Deficits in an Eae Model

Authors

Jiang Long Tu
Chong bo ZhaoFollow
Timothy Vollmer
Stephen CoonsFollow
Haojie Lin
Stephen Marsh
David M. Treiman, Barrow Neurological InstituteFollow
Jiong Shi, Barrow Neurological InstituteFollow

Department

neurology

Document Type

Article

Abstract

Recent clinical studies have identified an association between APOE 4 and cognitive deficits in patients with multiple sclerosis. We induced experimental autoimmune encephalomyelitis (EAE) in APOE knockout (KO) and human APOE 4 knockin (E4) mice to study the interaction of APOE and neuroinflammation on cognition. After EAE induction, KO and E4 showed significant deficits in spatial learning and recall. Regional decreases in choline acetyltransferase localized to the hippocampus. Induction of EAE in a transgenic APOE animal provides a template from which we can decipher the role APOE has on cognition in the context of neuroinflammation.

Medical Subject Headings

neurology

Publication Date

2009

Publication Title

Biochemical and Biophysical Research Communications

ISSN

0006-291X

Volume

384

Issue

4

First Page

466

Last Page

470

Digital Object Identifier (DOI)

10.1016/j.bbrc.2009.04.153

Recommended Citation

Tu, Jiang Long; Zhao, Chong bo; Vollmer, Timothy; Coons, Stephen; Lin, Haojie; Marsh, Stephen; Treiman, David M.; and Shi, Jiong, "Apoe 4 Polymorphism Results in Early Cognitive Deficits in an Eae Model" (2009). Neurology. 256.
https://scholar.barrowneuro.org/neurology/256