Title

BDNF Genetic Variants are Associated With Onset Age of Familial Parkinson Disease: GenePD Study

Department

neurology

Document Type

Article

Abstract

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

Medical Subject Headings

neurology

Publication Date

2005

Publication Title

Neurology

ISSN

0028-3878

Volume

65

Issue

11

First Page

1823

Last Page

1825

Digital Object Identifier (DOI)

10.1212/01.wnl.0000187075.81589.fd

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