Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease Dementia With Lewy Bodies and Other Lewy Body Disorders
Department
neurology
Document Type
Article
Abstract
Background: Clinical misdiagnosis, particularly at early disease stages, is a roadblock to finding new therapies for Lewy body disorders. Biopsy of a peripheral site might provide improved diagnostic accuracy. Previously, we reported, from both autopsy and needle biopsy, a high prevalence of submandibular gland synucleinopathy in Parkinson's disease (PD). Here, we report on an extension of these studies to subjects with dementia with Lewy bodies (DLB) and other Lewy body disorders in 228 autopsied subjects from the Arizona Study of Aging and Neurodegenerative Disorders. Objective: To provide an estimate of the prevalence of histological synucleinopathy in the submandibular glands of subjects with PD and other Lewy body disorders. Methods: Submandibular gland sections from autopsied subjects were stained with an immunohistochemical method for β-synuclein phosphorylated at serine 129. Included were 146 cases with CNS Lewy-type synucleinopathy (LTS), composed of 46 PD, 28 DLB, 14 incidental Lewy body disease (ILBD), 33 Alzheimer's disease with Lewy bodies (ADLB) and 2 with progressive supranuclear palsy and Lewy bodies (PSPLB). Control subjects included 79 normal elderly, 15 AD, 12 PSP, 2 conticobasal degeneration (CBD) and 2 multiple system atrophy (MSA). Results: Submandibular gland LTS was found in 42/47 (89%) of the PD subjects, 20/28 (71%) DLB, 4/33 (12%) ADLB and 1/9 (11%) ILBD subjects but none of the 110 control subjects. Conclusions: These results provide support for further clinical trials of in vivo submandibular gland diagnostic biopsy for PD and DLB. An accurate peripheral biopsy diagnosis would assist subject selection for clinical trials and could also be used to verify other biomarkers.
Medical Subject Headings
neurology
Publication Date
2016
Publication Title
Journal of Parkinson's Disease
ISSN
1877-7171
Volume
6
Issue
1
First Page
153
Last Page
163
Digital Object Identifier (DOI)
10.3233/JPD-150680
Recommended Citation
Beach, Thomas G.; Adler, Charles H.; Serrano, Geidy; Sue, Lucia I.; Walker, D. G.; Dugger, Brittany N.; Shill, Holly A.; Driver-Dunckley, Erika; Caviness, John N.; Intorcia, Anthony; Filon, Jessica; Scott, Sarah; Garcia, Angelica; Hoffman, Brittany; Belden, Christine M.; Davis, Kathryn J.; and Sabbagh, Marwan N., "Prevalence of Submandibular Gland Synucleinopathy in Parkinson's Disease Dementia With Lewy Bodies and Other Lewy Body Disorders" (2016). Neurology. 231.
https://scholar.barrowneuro.org/neurology/231