Reversible diffusion weighted imaging changes in propionic acidemia

Document Type

Article

Abstract

Propionic acidemia is an inborn error of metabolism with neurologic manifestations. We describe a 3-year-old boy with propionic acidemia presenting with a metabolic crisis including headache, vomiting, and altered mental status with metabolic acidosis. Electroencephalography showed focal slowing in right temporal region. Magnetic resonance imaging (MRI) of the brain showed restricted diffusion with apparent diffusion coefficient correlate in the right parietooccipital region. Correction of metabolic acidosis led to clinical improvement and normalization of MRI diffusion weighted imaging/apparent diffusion coefficient changes. This article suggests that restricted diffusion resulting from metabolic crises in propionic acidemia may be reversible in some cases.

Medical Subject Headings

Blood Cell Count; Child, Preschool; Diffusion Tensor Imaging (methods); Electroencephalography; Humans; Magnetic Resonance Imaging; Male; Propionic Acidemia (diagnosis, metabolism); Temporal Lobe (metabolism, pathology)

Publication Date

1-1-2013

Publication Title

Journal of child neurology

E-ISSN

1708-8283

Volume

28

Issue

1

First Page

128

Last Page

31

PubMed ID

22532545

Digital Object Identifier (DOI)

10.1177/0883073812441057

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