Pertussis Toxin Modulates Microglia and T Cell Profile to Protect Experimental Autoimmune Encephalomyelitis

Authors

Jun Xiang Yin
Zhiwei Tang
Yan Gan
Lejun Li
Fu-Dong Shi, Barrow Neurological InstituteFollow
Stephen CoonsFollow
Jiong Shi, Barrow Neurological InstituteFollow

Department

neurology

Document Type

Article

Abstract

Pertussis toxin (PTx) has various effects in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). This study was designed to explore the protective effects of PTx of different doses and subunits. EAE model was induced with myelin oligodendrocyte glycoprotein (MOG35-55, 200 ug) plus complete Freund's adjuvant in 6-7 week-old female C57BL/6 mice. PTx reduced clinical deficits of EAE by 91.3%. This reduction in clinical deficits was achieved by attenuating demyelination by 75.5%. Furthermore, PTx reduced the lymphocyte infiltration, deactivated microglia activation and changed T cell profile by increasing T helper (type 1 and 2) and T regulatory cells.

Medical Subject Headings

neurology

Publication Date

2014

Publication Title

Neuropharmacology

ISSN

0028-3908

Volume

81

First Page

1

Last Page

5

Digital Object Identifier (DOI)

10.1016/j.neuropharm.2014.01.027

Recommended Citation

Yin, Jun Xiang; Tang, Zhiwei; Gan, Yan; Li, Lejun; Shi, Fu-Dong; Coons, Stephen; and Shi, Jiong, "Pertussis Toxin Modulates Microglia and T Cell Profile to Protect Experimental Autoimmune Encephalomyelitis" (2014). Neurology. 186.
https://scholar.barrowneuro.org/neurology/186