Use of statin during hospitalization improves the outcome after intracerebral hemorrhage.

Document Type

Article

Abstract

AIMS: To examine the relationship between statin use in Chinese patients with intracerebral hemorrhage (ICH) during their hospitalization and the outcomes.

METHODS: Data were collected from the China National Stroke Registry. Good functional outcome was defined by a modified Rankin Scale score between 0-2. Functional outcome and rate of mortality at 3 months and 1 year were compared between ICH patients on statin and those without it during their hospitalization. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated using the multivariable logistic regression model adjusted for baseline risk factors.

RESULTS: Among 3218 consecutive ICH patients from 2007 to 2008, 220 (6.8%) were on statin during their hospitalization. Compared with those without statin, patients on statin were younger, had more stroke risk factors but lower stroke severity. ICH patients on statin had better functional outcome at 3 months (OR 2.24, 95% CI 1.49-3.36) and at 1 year (OR 2.04, 95% CI 1.37-3.06). They also had lower rate of mortality at 3 months (OR 0.44, 95% CI 0.22-0.87) and 1 year (OR 0.49, 95% CI 0.27-0.86).

CONCLUSIONS: In-hospital statin use in ICH patients is associated with better functional outcome and lower mortality at 3 months and 1 year.

Medical Subject Headings

Aged; Cerebral Hemorrhage; China; Female; Follow-Up Studies; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Outcome Assessment, Health Care; Registries; Retrospective Studies; Risk Factors; Severity of Illness Index; Statistics, Nonparametric; Treatment Outcome

Publication Date

6-1-2014

Publication Title

CNS Neurosci Ther

ISSN

1755-5949

Volume

20

Issue

6

First Page

548

Last Page

555

PubMed ID

24750990

Digital Object Identifier (DOI)

10.1111/cns.12274

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