Association Between Helicobacter Pylori Infection and Long-term Outcome in Patients with Drug-eluting Stent Implantation

Document Type

Article

Abstract

To investigate the relationship between Helicobacter pylori (Hp) infection and the long-term outcome in acute coronary syndrome (ACS) patients with drug-eluting stent (DES) implantation and so as to explore the significance of Hp eradication therapy in preventing major adverse cardiac events (MACE) and upper gastrointestinal bleeding (UGIB). 539 ACS patients with DES implantation from January 1, 2010 to December 31, 2012 were analyzed. All the patients were divided into two groups according to the result of C urea breath test. 253 patients with Hp infection were put into group A (Hp), and 286 cases without Hp infection were put into group B (Hp). Demographic data was collected and all patients went through biochemical indicators and other routine blood examinations. We explored the correlations of Hp infection with MACE and UGIB after 3 to 5 years of follow-up using survival analysis. Survival analysis showed that Hp infection was a predictor of MACE and UGI. Sub-group analysis showed that patients with Hp eradication therapy had no relationship with MACE but had a lower rate of UGIB than those without Hp eradication therapy.

Medical Subject Headings

Acute Coronary Syndrome (complications, diagnosis, mortality, therapy); Aged; Comorbidity; Coronary Angiography; Drug-Eluting Stents; Female; Follow-Up Studies; Helicobacter Infections (complications, diagnosis, microbiology); Helicobacter pylori; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Patient Outcome Assessment; Percutaneous Coronary Intervention; Proportional Hazards Models

Publication Date

7-13-2017

Publication Title

Scientific reports

E-ISSN

2045-2322

Volume

7

First Page

44954

PubMed ID

28703181

Digital Object Identifier (DOI)

10.1038/srep44954

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