Apoe Epsiolon-4 is Associated With Exacerbation of Cognitive Decline in Patients With Multiple Sclerosis
Background: In previous studies we and others have demonstrated an association with apolipoprotein (APOE) Îµ4 genotype and the presence of cognitive deficits in multiple sclerosis (MS). In this follow-up study, we have assessed whether APOE Îµ4 status exacerbates progression of cognitive deficits in MS. Methods: A total of 197 patients with MS were assessed for APOE genotype, and baseline cognitive performance was measured using a standardized battery of tests. One hundred seventy patients (86.3%) were clinically followed up for 1 year and were assessed for progression of cognitive deficits. Results: The APOE Îµ4 allele was present in 24.7% of patients. During 1-year follow-up, significant progression of cognitive deficits was found in APOE Îµ4 carriers (P=0.001) after logistic regression analysis controlling for sex, ethnicity, age, education, disease duration, severity, and subtype. Conclusions: APOE Îµ4 carriers with MS have worsening progression of cognitive deficits than noncarriers. APOE Îµ4 carrier status predicts cognitive decline in verbal learning and memory. Copyright Â© 2011 by Lippincott Williams & Wilkins.
Medical Subject Headings
Cognitive and Behavioral Neurology
Digital Object Identifier (DOI)
Shi, Jiong; Tu, Jiang Long; Gale, Shawn D.; Baxter, Leslie; Vollmer, Timothy L.; Campagnolo, Denise I.; Tyry, Tuula M.; Zhuang, Yi; and Kuniyoshi, Sandra M., "Apoe Epsiolon-4 is Associated With Exacerbation of Cognitive Decline in Patients With Multiple Sclerosis" (2011). Neurology. 176.