Title

Apoe Epsiolon-4 is Associated With Exacerbation of Cognitive Decline in Patients With Multiple Sclerosis

Department

neurology

Document Type

Article

Abstract

Background: In previous studies we and others have demonstrated an association with apolipoprotein (APOE) ε4 genotype and the presence of cognitive deficits in multiple sclerosis (MS). In this follow-up study, we have assessed whether APOE ε4 status exacerbates progression of cognitive deficits in MS. Methods: A total of 197 patients with MS were assessed for APOE genotype, and baseline cognitive performance was measured using a standardized battery of tests. One hundred seventy patients (86.3%) were clinically followed up for 1 year and were assessed for progression of cognitive deficits. Results: The APOE ε4 allele was present in 24.7% of patients. During 1-year follow-up, significant progression of cognitive deficits was found in APOE ε4 carriers (P=0.001) after logistic regression analysis controlling for sex, ethnicity, age, education, disease duration, severity, and subtype. Conclusions: APOE ε4 carriers with MS have worsening progression of cognitive deficits than noncarriers. APOE ε4 carrier status predicts cognitive decline in verbal learning and memory. Copyright © 2011 by Lippincott Williams & Wilkins.

Medical Subject Headings

neurology

Publication Date

2011

Publication Title

Cognitive and Behavioral Neurology

ISSN

15433633

Volume

24

Issue

3

First Page

128

Last Page

133

Digital Object Identifier (DOI)

10.1097/WNN.0b013e31823380b5

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