Apoe Epsiolon-4 is Associated With Exacerbation of Cognitive Decline in Patients With Multiple Sclerosis

Department

neurology

Document Type

Article

Abstract

Background: In previous studies we and others have demonstrated an association with apolipoprotein (APOE) ε4 genotype and the presence of cognitive deficits in multiple sclerosis (MS). In this follow-up study, we have assessed whether APOE ε4 status exacerbates progression of cognitive deficits in MS. Methods: A total of 197 patients with MS were assessed for APOE genotype, and baseline cognitive performance was measured using a standardized battery of tests. One hundred seventy patients (86.3%) were clinically followed up for 1 year and were assessed for progression of cognitive deficits. Results: The APOE ε4 allele was present in 24.7% of patients. During 1-year follow-up, significant progression of cognitive deficits was found in APOE ε4 carriers (P=0.001) after logistic regression analysis controlling for sex, ethnicity, age, education, disease duration, severity, and subtype. Conclusions: APOE ε4 carriers with MS have worsening progression of cognitive deficits than noncarriers. APOE ε4 carrier status predicts cognitive decline in verbal learning and memory.

Medical Subject Headings

neurology

Publication Date

2011

Publication Title

Cognitive and Behavioral Neurology

ISSN

1543-3633

Volume

24

Issue

3

First Page

128

Last Page

133

Digital Object Identifier (DOI)

10.1097/WNN.0b013e31823380b5

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