Challenges of targeting V600E mutations in adult primary brain tumor patients: a report of two cases

Authors

Matthew Smith-Cohn, Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.Follow
Christian Davidson, Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
Howard Colman, Department of Neurosurgery, Huntsman Cancer Institute, & Clinical Neuroscience Center, University of Utah, Salt Lake City, UT 84112, USA.
Adam L. Cohen, Division of Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

Document Type

Article

Abstract

Therapeutic targeting of alterations in primary brain tumor patients has demonstrated clinical activity in case reports and early trials; however, there is limited high-level evidence of the efficacy. Targeting V600E mutations with concurrent dabrafenib and trametinib in anaplastic pleomorphic xanthoastrocytoma resulted in a transient radiographic and clinical response and no therapeutic benefit in a patient with an epithelioid glioblastoma. / inhibition did not produce a durable treatment effect in glioblastoma or pleomorphic xanthoastrocytoma with alterations. Heterogenicity of related cases in the literature makes an evaluation of efficacy targeting therapies in gliomas difficult and requires additional investigation.

Medical Subject Headings

Astrocytoma (diagnostic imaging, drug therapy, genetics, surgery); Brain Neoplasms (diagnostic imaging, drug therapy, genetics, surgery); Female; Humans; Imidazoles (therapeutic use); Male; Middle Aged; Mutation; Oximes (therapeutic use); Protein Kinase Inhibitors (therapeutic use); Proto-Oncogene Proteins B-raf (genetics); Pyridones (therapeutic use); Pyrimidinones (therapeutic use); Treatment Failure; Young Adult

Publication Date

12-1-2019

Publication Title

CNS oncology

E-ISSN

2045-0915

Volume

8

Issue

4

First Page

CNS48

PubMed ID

31818130

Digital Object Identifier (DOI)

10.2217/cns-2019-0018

Recommended Citation

Smith-Cohn, Matthew; Davidson, Christian; Colman, Howard; and Cohen, Adam L., "Challenges of targeting V600E mutations in adult primary brain tumor patients: a report of two cases" (2019). Neurology. 1745.
https://scholar.barrowneuro.org/neurology/1745