Association Between Serum Calcium Level and Extent of Bleeding in Patients With Intracerebral Hemorrhage

Authors

Andrea Morotti, Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy2Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston3J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
Andreas Charidimou, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
Chia-Ling Phuah, Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston3J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.Follow
Michael J. Jessel, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
Kristin Schwab, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
Alison M. Ayres, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
Javier M. Romero, Neuroradiology Service, Department of Radiology, Massachusetts General Hospital, Boston.
Anand Viswanathan, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
M Edip Gurol, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
Steven M. Greenberg, J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
Christopher D. Anderson, Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston3J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
Jonathan Rosand, Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston3J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston.
Joshua N. Goldstein, Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts General Hospital, Boston3J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston5Department of Emergency Medicine, Massachusetts General Hospital, Boston.

Document Type

Article

Abstract

IMPORTANCE: Calcium is a key cofactor of the coagulation cascade and may play a role in the pathophysiology of intracerebral hemorrhage (ICH). OBJECTIVE: To investigate whether a low serum calcium level is associated with an increase in the extent of bleeding in patients with ICH as measured by baseline hematoma volume and risk of hematoma expansion. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study of 2103 consecutive patients with primary ICH ascertained during the period between 1994 and 2015 at an academic medical center. The statistical analysis was performed in January 2016. MAIN OUTCOMES AND MEASURES: Total calcium level was measured on admission, and hypocalcemia was defined as a serum calcium level of less than 8.4 mg/dL. Baseline and follow-up hematoma volumes, detected by noncontrast computed tomography, were measured using a computer-assisted semiautomatic analysis. Hematoma expansion was defined as an increase of more than 30% or 6 mL from baseline ICH volume. Associations between serum calcium level and baseline hematoma volume and between serum calcium level and ICH expansion were investigated in multivariable linear and logistic regression models, respectively. RESULTS: A total of 2123 patients with primary ICH were screened, and 2103 patients met the inclusion criteria (mean [SD] age, 72.7 [12.5] years; 54.3% male patients), of whom 229 (10.9%) had hypocalcemia on admission. Hypocalcemic patients had a higher median baseline hematoma volume than did normocalcemic patients (37 mL [IQR, 15-72 mL] vs 16 mL [IQR, 6-44 mL]; P < .001). Low calcium levels were independently associated with higher baseline ICH volume (β = -0.13, SE = .03, P < .001). A total of 1393 patients underwent follow-up noncontrast computed tomography and were included in the ICH expansion analysis. In this subgroup, a higher serum calcium level was associated with reduced risk of ICH expansion (odds ratio, 0.55 [95% CI, 0.35-0.86]; P = .01), after adjusting for other confounders. CONCLUSIONS AND RELEVANCE: Hypocalcemia correlates with the extent of bleeding in patients with ICH. A low calcium level may be associated with a subtle coagulopathy predisposing to increased bleeding and might therefore be a promising therapeutic target for acute ICH treatment trials.

Medical Subject Headings

Aged; Aged, 80 and over; Calcium (blood); Cerebral Hemorrhage (blood, diagnostic imaging); Cohort Studies; Female; Humans; Hypocalcemia (blood, complications); Male; Middle Aged

Publication Date

11-1-2016

Publication Title

JAMA neurology

E-ISSN

2168-6157

Volume

73

Issue

11

First Page

1285

Last Page

1290

PubMed ID

27598746

Digital Object Identifier (DOI)

10.1001/jamaneurol.2016.2252

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