Neuro-ophthalmic sarcoidosis

Document Type

Article

Abstract

Neuro-ophthalmic disease occurs in about a third of patients with neurosarcoidosis. Optic nerve involvement is the most common manifestation, but other cranial nerves and the optic chiasm can be involved. However, there are several other common diseases that cause optic neuropathy, including multiple sclerosis. The diagnosis of sarcoidosis can often be made based on the multi-organ nature of the disease and ancillary testing. Most patients with neuro-ophthalmic sarcoidosis require systemic therapy. While corticosteroids are usually the first step in therapy, cytotoxic agents such as methotrexate and azathioprine have been useful as steroid-sparing agents for chronic disease. The monoclonal antibodies directed against tumor necrosis factor have been reported as effective in refractory cases of neuro-ophthalmic disease.

Publication Date

1-1-2012

Publication Title

Eye and brain

ISSN

1179-2744

Volume

4

First Page

13

Last Page

25

PubMed ID

28539778

Digital Object Identifier (DOI)

10.2147/EB.S29401

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