The usefulness of immunotherapy in pediatric neurodegenerative disorders: A systematic review of literature data

Authors

Giovanna Vitaliti, Acute and Emergency Paediatric and General Paediatric Operative Unit; Policlinico-Vittorio Emanuele Hospital; University of Catania ; Catania , Italy.
Omidreza Tabatabaie, School of Medicine; Tehran University of Medical Sciences ; Tehran , Iran.
Nassim Matin, School of Medicine; Tehran University of Medical Sciences ; Tehran , Iran.
Caterina Ledda, Hygiene and Public Health; Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia"; University of Catania ; Catania , Italy.
Piero Pavone, Acute and Emergency Paediatric and General Paediatric Operative Unit; Policlinico-Vittorio Emanuele Hospital; University of Catania ; Catania , Italy.
Riccardo Lubrano, Pediatric Department ; Pediatric Nephrology Operative Unit of the Sapienza University of Rome ; Rome , Italy.
Agostino Serra, ENT Department G.F. Ingrassia ; Policlinico-Vittorio Emanuele University Hospital; University of Catania ; Catania , Italy.
Paola Di Mauro, ENT Department G.F. Ingrassia ; Policlinico-Vittorio Emanuele University Hospital; University of Catania ; Catania , Italy.
Salvatore Cocuzza, ENT Department G.F. Ingrassia ; Policlinico-Vittorio Emanuele University Hospital; University of Catania ; Catania , Italy.
Raffaele Falsaperla, Acute and Emergency Paediatric and General Paediatric Operative Unit; Policlinico-Vittorio Emanuele Hospital; University of Catania ; Catania , Italy.

Document Type

Article

Abstract

Immunotherapeutic strategies to treat neurodegenerative disorders have inspired the scientific community. The aim of our review is to address the translational aspects of neuroimmunology to describe the efficacy of immunotherapy in the treatment of pediatric neurodegenerative disorders. In the studies we analyzed IVIG were found to be efficient in the treatment of post-streptococcal neurodegenerative disorders, even if in PANDAS, plasma-exchange (PE) showed a higher efficiency. IVIG were also successfully used in ADEM and Guillan-Barré syndrome. In Sydenham Chorea the use of methylprednisolone was found in most cases as efficient as IVIG, while in Tourette's Syndrome, Colecoxib was successfully used in one patient. Pediatric Multiple Sclerosis seems to respond better to immunosuppressant agents (Mitoxantrone, Cyclophosphamide, Natalizumab), as well as Neuromyelitis optica (Rituximab, Mycofenolate). The importance of this review relies in the attempt to draw standardized guidelines for immunotherapy in pediatric neurodegeneratve disorders.

Medical Subject Headings

Autoimmune Diseases (drug therapy); Child; Chorea (drug therapy); Cyclophosphamide (therapeutic use); Guillain-Barre Syndrome (therapy); Humans; Immunoglobulins, Intravenous (therapeutic use); Immunotherapy (methods); Methylprednisolone (therapeutic use); Mitoxantrone (therapeutic use); Multiple Sclerosis (drug therapy, immunology); Natalizumab (therapeutic use); Nervous System (immunology, pathology); Neurodegenerative Diseases (drug therapy, immunology); Neuromyelitis Optica (drug therapy); Obsessive-Compulsive Disorder; Plasma Exchange (methods); Rituximab (therapeutic use); Streptococcal Infections (drug therapy); Tourette Syndrome (drug therapy)

Publication Date

1-1-2015

Publication Title

Human vaccines & immunotherapeutics

E-ISSN

2164-554X

Volume

11

Issue

12

First Page

2749

Last Page

63

PubMed ID

26266339

Digital Object Identifier (DOI)

10.1080/21645515.2015.1061161

Recommended Citation

Vitaliti, Giovanna; Tabatabaie, Omidreza; Matin, Nassim; Ledda, Caterina; Pavone, Piero; Lubrano, Riccardo; Serra, Agostino; Di Mauro, Paola; Cocuzza, Salvatore; and Falsaperla, Raffaele, "The usefulness of immunotherapy in pediatric neurodegenerative disorders: A systematic review of literature data" (2015). Neurology. 1517.
https://scholar.barrowneuro.org/neurology/1517