Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease
Document Type
Article
Abstract
OBJECTIVES: To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). DESIGN: Retrospective chart review. SETTING: Community-based memory clinic. PARTICIPANTS: Individuals meeting Petersen's MCI criteria (N = 165). MEASUREMENTS: Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD. RESULTS: One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18 months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%). CONCLUSION: Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD.
Medical Subject Headings
Aged; Alzheimer Disease (diagnosis, epidemiology, psychology); Cognition (physiology); Cognitive Dysfunction (diagnosis, epidemiology, psychology); Disease Progression; Female; Follow-Up Studies; Geriatric Assessment (methods); Humans; Incidence; Magnetic Resonance Imaging; Male; Memory (physiology); Neuropsychological Tests; Predictive Value of Tests; Prognosis; Quebec (epidemiology); Retrospective Studies; Surveys and Questionnaires; Tomography, X-Ray Computed
Publication Date
4-1-2014
Publication Title
Journal of the American Geriatrics Society
E-ISSN
1532-5415
Volume
62
Issue
4
First Page
679
Last Page
84
PubMed ID
24635004
Digital Object Identifier (DOI)
10.1111/jgs.12742
Recommended Citation
Julayanont, Parunyou; Brousseau, Mélanie; Chertkow, Howard; Phillips, Natalie; and Nasreddine, Ziad S., "Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a predictor of conversion from mild cognitive impairment to Alzheimer's disease" (2014). Neurology. 1241.
https://scholar.barrowneuro.org/neurology/1241