Title

Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease.

Document Type

Article

Abstract

A mutation within the alpha-synuclein gene on human chromosome 4 has been reported to segregate with PD in an Italian family. We screened a sample of familial cases of PD for mutation in the alpha-synuclein gene. None of the familial cases of PD carried a mutation within the alpha-synuclein gene, and no association was detected between PD and alleles of a dinucleotide repeat marker within the alpha-synuclein gene. We conclude that variation within the alpha-synuclein gene does not play a significant role in the risk for PD in our sample.

Medical Subject Headings

Aged; Alleles; Chromosomes, Human, Pair 4; DNA Mutational Analysis; Family Health; Female; Humans; Italy; Male; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Phosphoproteins; Point Mutation; Polymorphism, Genetic; Synucleins; alpha-Synuclein

Publication Date

12-1-1998

Publication Title

Neurology

ISSN

0028-3878

Volume

51

Issue

6

First Page

1757

Last Page

1759

PubMed ID

9855543

Digital Object Identifier (DOI)

10.1212/wnl.51.6.1757

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