Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease.
Document Type
Article
Abstract
A mutation within the alpha-synuclein gene on human chromosome 4 has been reported to segregate with PD in an Italian family. We screened a sample of familial cases of PD for mutation in the alpha-synuclein gene. None of the familial cases of PD carried a mutation within the alpha-synuclein gene, and no association was detected between PD and alleles of a dinucleotide repeat marker within the alpha-synuclein gene. We conclude that variation within the alpha-synuclein gene does not play a significant role in the risk for PD in our sample.
Medical Subject Headings
Aged; Alleles; Chromosomes, Human, Pair 4; DNA Mutational Analysis; Family Health; Female; Humans; Italy; Male; Middle Aged; Nerve Tissue Proteins; Parkinson Disease; Phosphoproteins; Point Mutation; Polymorphism, Genetic; Synucleins; alpha-Synuclein
Publication Date
12-1-1998
Publication Title
Neurology
ISSN
0028-3878
Volume
51
Issue
6
First Page
1757
Last Page
1759
PubMed ID
9855543
Digital Object Identifier (DOI)
10.1212/wnl.51.6.1757
Recommended Citation
Parsian, A; Racette, B; Zhang, Z H; Chakraverty, S; Rundle, M; Goate, A; and Perlmutter, J S, "Mutation, sequence analysis, and association studies of alpha-synuclein in Parkinson's disease." (1998). Neurology. 1213.
https://scholar.barrowneuro.org/neurology/1213