Parkinson disease and cognitive impairment: Five new things.

Document Type

Article

Abstract

PURPOSE OF REVIEW: While the distinctive motor symptoms of Parkinson disease (PD) have been described for centuries, cognitive impairment has only recently been recognized as a central feature. Studies have yielded clues to the etiology and natural history of cognitive impairment in PD, but much remains unclear and effective therapies are needed.

RECENT FINDINGS: Longitudinal cohort studies demonstrate that almost all patients with PD will develop dementia if they live long enough. New CSF biomarker and genetic studies suggest that it may soon be possible to forecast and track the progression of dementia in PD. Sleep and sleep disturbance appear to be intrinsically linked with PD, although the implications for individual outcomes and opportunities for intervention are unclear. Multidisciplinary treatment approaches incorporating cognitive training may help to improve outcomes.

SUMMARY: We review several recent advances in understanding the pathophysiology, genetics, and management of cognitive impairment in PD.

Publication Date

10-1-2016

Publication Title

Neurol Clin Pract

ISSN

2163-0402

Volume

6

Issue

5

First Page

452

Last Page

458

PubMed ID

27847686

Digital Object Identifier (DOI)

10.1212/CPJ.0000000000000285

This document is currently not available here.

Share

COinS