Immunosuppressants and risk of Parkinson disease

Authors

Brad A. Racette, Department of Neurology Washington University School of Medicine 660 South Euclid Avenue, Campus Box 8111 St. Louis Missouri 63110.
Anat Gross, Department of Neurology Washington University School of Medicine 660 South Euclid Avenue, Campus Box 8111 St. Louis Missouri 63110.
Scott Martin Vouri, Center for Health Outcomes Research and Education Department of Pharmacy Practice St. Louis College of Pharmacy 4588 Parkview Place St. Louis Missouri 63110.
Alejandra Camacho-Soto, Department of Neurology Washington University School of Medicine 660 South Euclid Avenue, Campus Box 8111 St. Louis Missouri 63110.
Allison W. Willis, Department of Neurology University of Pennsylvania Perelman School of Medicine 423 Guardian Drive Philadelphia Pennsylvania 19104.
Susan Searles Nielsen, Department of Neurology Washington University School of Medicine 660 South Euclid Avenue, Campus Box 8111 St. Louis Missouri 63110.

Document Type

Article

Abstract

We performed a population-based case-control study of United States Medicare beneficiaries age 60-90 in 2009 with prescription data (48,295 incident Parkinson disease cases and 52,324 controls) to examine the risk of Parkinson disease in relation to use of immunosuppressants. Inosine monophosphate dehydrogenase inhibitors (relative risk = 0.64; 95% confidence interval 0.51-0.79) and corticosteroids (relative risk = 0.80; 95% confidence interval 0.77-0.83) were both associated with a lower risk of Parkinson disease. Inverse associations for both remained after applying a 12-month exposure lag. Overall, this study provides evidence that use of corticosteroids and inosine monophosphate dehydrogenase inhibitors might lower the risk of Parkinson disease.

Publication Date

7-1-2018

Publication Title

Annals of clinical and translational neurology

ISSN

2328-9503

Volume

5

Issue

7

First Page

870

Last Page

875

PubMed ID

30009205

Digital Object Identifier (DOI)

10.1002/acn3.580

Recommended Citation

Racette, Brad A.; Gross, Anat; Vouri, Scott Martin; Camacho-Soto, Alejandra; Willis, Allison W.; and Searles Nielsen, Susan, "Immunosuppressants and risk of Parkinson disease" (2018). Neurology. 1137.
https://scholar.barrowneuro.org/neurology/1137