Iatrogenic botulism due to therapeutic botulinum toxin a injection in a pediatric patient
Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.
Medical Subject Headings
Botulinum Toxins, Type A (adverse effects); Botulism (chemically induced); Cerebral Palsy (drug therapy); Child, Preschool; Female; Humans
Digital Object Identifier (DOI)
Crowner, Beth E.; Brunstrom, Janice E.; and Racette, Brad A., "Iatrogenic botulism due to therapeutic botulinum toxin a injection in a pediatric patient" (2007). Neurology. 1136.