Iatrogenic botulism due to therapeutic botulinum toxin a injection in a pediatric patient

Authors

Beth E. Crowner, Program in Physical Therapy, Department of Neurology, Washington University School of Medicine, 660 S. Euclid Avenue, St Louis, MO 63110, USA.
Janice E. Brunstrom
Brad A. Racette

Document Type

Article

Abstract

Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.

Medical Subject Headings

Botulinum Toxins, Type A (adverse effects); Botulism (chemically induced); Cerebral Palsy (drug therapy); Child, Preschool; Female; Humans

Publication Date

9-1-2007

Publication Title

Clinical neuropharmacology

ISSN

0362-5664

Volume

30

Issue

5

First Page

310

Last Page

3

PubMed ID

17909312

Digital Object Identifier (DOI)

10.1097/WNF.0b013e31804b1a0d

Recommended Citation

Crowner, Beth E.; Brunstrom, Janice E.; and Racette, Brad A., "Iatrogenic botulism due to therapeutic botulinum toxin a injection in a pediatric patient" (2007). Neurology. 1136.
https://scholar.barrowneuro.org/neurology/1136