Clinical features and comorbidity of mood fluctuations in Parkinson's disease

Authors

Brad A. Racette, Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St. Louis, MO 63110, USA. racetteb@neuro.wustl.edu
Johanna M. Hartlein
Tamara Hershey
Jonathan W. Mink
Joel S. Perlmutter
Kevin J. Black

Document Type

Article

Abstract

Parkinson's disease (PD) patients commonly develop fluctuations in their motor responses to levodopa within several years of initiation of treatment; some also develop nonmotor fluctuations. The authors performed a case-control study comparing the frequency of comorbid symptoms in 70 PD patients who experienced clinically apparent mood changes during their motor "on" or "off" states with two control groups with no mood fluctuations. Mood fluctuators had significantly younger age at onset and longer disease duration and were significantly more likely to have dementia, psychosis, clinical depression, and motor complications. This association remained after removing effects of age and disease duration.

Medical Subject Headings

Adult; Aged; Aged, 80 and over; Comorbidity; Female; Humans; Hypokinesia (epidemiology); Male; Middle Aged; Mood Disorders (diagnosis, epidemiology, psychology); Parkinson Disease (epidemiology, psychology); Severity of Illness Index; Tremor (epidemiology)

Publication Date

1-1-2002

Publication Title

The Journal of neuropsychiatry and clinical neurosciences

ISSN

0895-0172

Volume

14

Issue

4

First Page

438

Last Page

42

PubMed ID

12426412

Digital Object Identifier (DOI)

10.1176/jnp.14.4.438

Recommended Citation

Racette, Brad A.; Hartlein, Johanna M.; Hershey, Tamara; Mink, Jonathan W.; Perlmutter, Joel S.; and Black, Kevin J., "Clinical features and comorbidity of mood fluctuations in Parkinson's disease" (2002). Neurology. 1110.
https://scholar.barrowneuro.org/neurology/1110