The effect of statins on rate of cognitive decline in mild cognitive impairment

Document Type

Article

Abstract

Introduction This study's aims are to identify whether a relationship between statin use and rate of cognitive decline exists. The relationship between statins and mild cognitive impairment (MCI) has been investigated in the past with the evidence showing mixed results. Methods Seven hundred sixty-eight subjects were identified with MCI. Subjects were stratified into six possible groups according to apolipoprotein E (APOE) ε4 allele status and statin use and assessed for decline in cognitive function. Results All cognitive assessments trended toward less decline with statin use. Alzheimer's Disease Assessment Scale 11 (ADAS 11) showed the biggest difference in mean change between statin users and nonusers (−0.82 vs. −1.22, respectively). Change reached marginal significance on the ADAS 11 when stratified by APOE ε4–negative subjects. Discussion All cognitive assessments trended toward less decline when subjects were concurrently treated with a statin, supporting the position that statins do not have a net negative effect on cognitive assessment and suggesting a potential treatment benefit.

Publication Date

6-1-2017

Publication Title

Alzheimer's and Dementia: Translational Research and Clinical Interventions

E-ISSN

23528737

Volume

3

Issue

2

First Page

149

Last Page

156

PubMed ID

28480324

Digital Object Identifier (DOI)

10.1016/j.trci.2017.01.001

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