Title

Smoking affects the phenotype of Alzheimer disease

Document Type

Article

Abstract

Because epidemiologic and in vitro evidence conflict, the authors studied the association between smoking and Alzheimer disease (AD) in 46 never, 47 former, and 15 active smokers with AD followed to autopsy. Disease parameters were examined by smoking status and amount smoked in bivariate tests and in multivariate models controlling for age, sex, education, and APOE status. Smoking status was not associated with cognitive or neuropathologic measures. However, active smokers were significantly younger at death and higher levels of smoking were associated with shorter disease duration. Copyright © 2005 by AAN Enterprises, Inc.

Publication Date

4-12-2005

Publication Title

Neurology

ISSN

00283878

Volume

64

Issue

7

First Page

1301

Last Page

1303

PubMed ID

15824373

Digital Object Identifier (DOI)

10.1212/01.WNL.0000156912.54593.65

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