Quantitative appraisal of ventricular cerebrospinal fluid biomarkers in neuropathologically diagnosed Parkinson's disease cases lacking Alzheimer's disease pathology
Document Type
Article
Abstract
Identifying biomarkers that distinguish Parkinson's disease (PD) from normal control (NC) individuals has the potential to increase diagnostic sensitivity for the detection of early-stage PD. A previous proteomic study identified potential biomarkers in post- mortem ventricular cerebrospinal fluid (V-CSF) from neuropathologically diagnosed PD subjects lacking Alzheimer's disease (AD) neuropathology. In the present study, we assessed these biomarkers as well as p-tau181, Aβ42, and S100B by ELISA in PD (n = 43) and NC (n = 49) cases. The p-tau181/Aβ42 ratio and ApoA-1 showed statistically significant differences between groups. Multiple regression analysis demonstrated that p-tau181/Aβ42 had a significant odds ratio: OR = 1.42 (95% confidence interval [CI], 1.12-1.84), P = 0.006. Among the molecules investigated, intriguing correlations were observed that require further investigation. Our results suggest co- existent AD CSF biomarkers within the PD group notwithstanding that it was selected to minimize AD neuropathological lesions. © the author(s), publisher and licensee Libertas Academica Ltd.
Publication Date
3-25-2013
Publication Title
Biomarker Insights
ISSN
11772719
Volume
8
First Page
19
Last Page
28
PubMed ID
23533154
Digital Object Identifier (DOI)
10.4137/BMI.S11422
Recommended Citation
Maarouf, Chera L.; Beach, Thomas G.; Adler, Charles H.; Malek-Ahmadi, Michael; Kokjohn, Tyler A.; Dugger, Brittany N.; Walker, Douglas G.; Shill, Holly A.; Jacobson, Sandra A.; Sabbagh, Marwan N.; and Roher, Alex E., "Quantitative appraisal of ventricular cerebrospinal fluid biomarkers in neuropathologically diagnosed Parkinson's disease cases lacking Alzheimer's disease pathology" (2013). Neurology. 1010.
https://scholar.barrowneuro.org/neurology/1010